abstract：:Extramedullary hematopoiesis (EMH) is a relatively rare, but well-documented, manifestation of chronic myeloproliferative disorders. Microscopically, foci of EMH consist of erythroid and myeloid precursors intermixed with megakaryocytes. It typically occurs in the spleen and liver, but very occasionally manifests as c...

journal_title：Journal of the American Academy of Dermatology

authors： Kawakami T,Kimura S,Kato M,Mizoguchi M,Soma Y

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Submissions to the Journal of the American Academy of Dermatology (JAAD) undergo a rigorous peer-review process. However, little is known regarding the fate of manuscripts declined by the JAAD. OBJECTIVE:We sought to: (1) determine the proportion of manuscripts declined by the JAAD that are subsequently pub...

journal_title：Journal of the American Academy of Dermatology

authors： Armstrong AW,Idriss SZ,Kimball AB,Bernhard JD

更新日期：2008-04-01 00:00:00

abstract：:Nasal and perinasal defects provide the dermatologic surgeon a challenge. It is necessary that the dermatologic surgeon assess each defect and patient individually for optimal repair. Many reconstructive options exist. This report demonstrates the technique of the transposition island pedicle flap which may be useful ...

journal_title：Journal of the American Academy of Dermatology

authors： Campbell LB,Ramsey ML

更新日期：2008-03-01 00:00:00

abstract：:Isolated plantar cerebriform collagenomas are a relatively rare type of connective tissue nevus. They have been suggested to be pathognomonic of Proteus syndrome. However, their presence is now considered to be a major criterion of Proteus syndrome, but the diagnosis of Proteus syndrome also requires the presence of o...

journal_title：Journal of the American Academy of Dermatology

authors： Nelson AA,Ruben BS

更新日期：2008-03-01 00:00:00

abstract：:Diabetic dermopathy (DD) is the most common cutaneous manifestation of diabetes mellitus. DD refers to atrophic, hyperpigmented macules characteristically located on the shins of patients with diabetes. They have an unfavorable association with the 3 most common microangiopathic complications of diabetes mellitus: neu...

journal_title：Journal of the American Academy of Dermatology

authors： Morgan AJ,Schwartz RA

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Glial cell line-derived neurotrophic factor (GDNF) and a related family member, neurturin (NTN), and their cognate receptors (GFRalpha-1 and GFRalpha-2, for GDNF and NTN, respectively) are distal members of the transforming growth factor-beta superfamily. They are involved in the control of murine hair folli...

journal_title：Journal of the American Academy of Dermatology

authors： Adly MA,Assaf HA,Pertile P,Hussein MR,Paus R

更新日期：2008-02-01 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) is a poorly understood neurovascular disorder characterized by pain, altered sensation, motor disturbance, soft tissue changes, vasomotor changes, and autonomic changes that occurs after trauma to an extremity. Unilateral leukonychia, Beau's lines, nailfold swelling, and nail clubbin...

journal_title：Journal of the American Academy of Dermatology

authors： Pucevich B,Spencer L,English JC 3rd

更新日期：2008-02-01 00:00:00

abstract：:Juvenile xanthogranuloma is a histiocytic tumor that usually appears at birth or during the first year of life. Although most patients have solitary lesions, some have multiple cutaneous lesions, associated visceral lesions, or both. Although juvenile xanthogranulomas are usually confined to the skin; visceral involve...

journal_title：Journal of the American Academy of Dermatology

authors： Haughton AM,Horii KA,Shao L,Daniel J,Nopper AJ

更新日期：2008-02-01 00:00:00

abstract：:A 4-year-old girl with failure to thrive and intense pruritus associated with Alagille syndrome is described. The clinical features of this autosomal dominant disorder are reviewed. This case highlights the importance of recognizing the severe pruritus as a manifestation of the disease. ...

journal_title：Journal of the American Academy of Dermatology

authors： Schwartz R,Rehder K,Parsons DJ,Morrell DS

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Dengue fever is the most common identifiable cause of acute febrile illness among travelers returning from South America, South Central Asia, Southeast Asia, and the Caribbean. Although the characteristic exanthem of dengue fever occurs in up to 50% of patients, few descriptions of it are found in the dermat...

journal_title：Journal of the American Academy of Dermatology

authors： Pincus LB,Grossman ME,Fox LP

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Onychomycosis (fungal infection of the toenails or fingernails) is common, affecting up to 8% of the general population. Telephone and mailed surveys conducted to study this disease are usually completed via patient self-report. The validity of the counts of diseased nails reported by the patients participat...

journal_title：Journal of the American Academy of Dermatology

authors： Cham PM,Chen SC,Grill JP,Warshaw EM

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The current diagnostic criteria for dermatomyositis (DM) exclude patients without muscle involvement. As a result there is a paucity of research related to the complete spectrum of the disease. OBJECTIVE:The goal of this study was to evaluate differences in the clinical manifestations of DM seen by dermatol...

journal_title：Journal of the American Academy of Dermatology

authors： Klein RQ,Teal V,Taylor L,Troxel AB,Werth VP

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disorder of unknown origin. OBJECTIVE:We conducted an investigation of skin biopsy specimens from 7 patients with NXG for the presence of Borrelia by focus-floating microscopy. METHODS:Focus-floating microscopy is a recently described, modified immuno...

journal_title：Journal of the American Academy of Dermatology

authors： Zelger B,Eisendle K,Mensing C,Zelger B

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Physician visits provide invaluable opportunities to screen patients for skin cancer, yielding earlier detection and improved survival. OBJECTIVE:We sought to assess frequency of skin cancer screening by full body skin examinations (FBSE) by primary care physicians, patient attitudes toward FBSE, and risk f...

journal_title：Journal of the American Academy of Dermatology

authors： Rodriguez GL,Ma F,Federman DG,Rouhani P,Chimento S,Multach M,Kirsner RS

更新日期：2007-11-01 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) often involves the skin. Cases with skin lesions without either leukemic nor lymph node involvement have been categorized into a cutaneous type. While the clinical manifestations of the cutaneous-type ATLL are variable, including multiple papules, nodules, plaques, or erythroderma...

journal_title：Journal of the American Academy of Dermatology

authors： Shimizu S,Yasui C,Koizumi K,Ikeda H,Tsuchiya K

更新日期：2007-11-01 00:00:00

abstract：:We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, ...

journal_title：Journal of the American Academy of Dermatology

authors： Kunishige JH,Hymes SR,Madkan V,Wyatt AJ,Uptmore D,Lazar AJ,Giralt S,Rady P,Tyring S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Very few studies have focused on fat redistribution induced by corticosteroids. OBJECTIVE:To establish the incidence and risk factors of facial ("moon face") and cervical ("buffalo hump") lipodystrophy due to long-term (> or =3 months), high dosage (>or =20 mg/d) systemic corticosteroid therapy. METHODS:Be...

journal_title：Journal of the American Academy of Dermatology

authors： Fardet L,Cabane J,Lebbé C,Morel P,Flahault A

更新日期：2007-10-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations simil...

journal_title：Journal of the American Academy of Dermatology

authors： Wadhera A,Maverakis E,Mitsiades N,Lara PN,Fung MA,Lynch PJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Lentigo maligna (LM) is a relatively common tumor with increasing prevalence and substantial morbidity. A variety of treatment modalities are available, though margin-control surgery offers the highest cure rate. We were interested in comparing long-term outcomes of Mohs micrographic surgery (MMS) versus sta...

journal_title：Journal of the American Academy of Dermatology

authors： Walling HW,Scupham RK,Bean AK,Ceilley RI

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Complications associated with psoriatic arthritis (PsA) may be prevented with early diagnosis and initiation of therapy. Up to one third of psoriasis patients may have PsA. There is a need to screen psoriasis patients early for symptoms of PsA. OBJECTIVE:To develop and validate a patient self-administered t...

journal_title：Journal of the American Academy of Dermatology

authors： Husni ME,Meyer KH,Cohen DS,Mody E,Qureshi AA

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The pathologic evaluation of mycosis fungoides (MF) is a challenging area in dermatopathology. OBJECTIVE:We sought to determine the usefulness of flow cytometry for the diagnosis of MF from skin biopsy specimens. METHODS:Skin biopsy specimens from 22 patients with a clinical suggestion for MF were evaluate...

journal_title：Journal of the American Academy of Dermatology

authors： Oshtory S,Apisarnthanarax N,Gilliam AC,Cooper KD,Meyerson HJ

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Seborrheic dermatitis is commonly treated with anti-inflammatory products, including topical corticosteroids. Pimecrolimus cream 1% also exerts anti-inflammatory activity by inhibiting T-cell cytokine production. OBJECTIVE:We sought to compare the efficacy and safety of twice-daily pimecrolimus for treatmen...

journal_title：Journal of the American Academy of Dermatology

authors： Warshaw EM,Wohlhuter RJ,Liu A,Zeller SA,Wenner RA,Bowers S,Schultz JC,Katz HI,McCormick CL,Parneix-Spake A

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Acne is one of the most common concerns of patients with body dysmorphic disorder (BDD), a psychiatric condition defined as a preoccupation with a slight or imagined defect in appearance that causes significant disruption in daily functioning. OBJECTIVE:We sought to screen for BDD symptoms among patients wi...

journal_title：Journal of the American Academy of Dermatology

authors： Bowe WP,Leyden JJ,Crerand CE,Sarwer DB,Margolis DJ

更新日期：2007-08-01 00:00:00

abstract：:Lipedema is characterized by symmetric lower extremity enlargement secondary to the deposition of fat. Lipedema is not rare, but it is commonly misdiagnosed as lymphedema. We describe a 20-year-old woman with massive lower extremity enlargement that did not respond to compression therapy. Magnetic resonance imaging of...

journal_title：Journal of the American Academy of Dermatology

authors： Fonder MA,Loveless JW,Lazarus GS

更新日期：2007-08-01 00:00:00

abstract：:Psoriasis has been traditionally viewed as an inflammatory skin disorder of unknown origin. Recent advances in the immunopathogenesis and genetics of psoriasis have broadened our understanding of psoriasis. Psoriasis is now considered a systemic inflammatory condition analogous to other inflammatory immune disorders. ...

journal_title：Journal of the American Academy of Dermatology

authors： Kremers HM,McEvoy MT,Dann FJ,Gabriel SE

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Efficacy of oral antiviral therapies, ie, acyclovir, valacyclovir (VACV), and famciclovir, for suppression of recurrent genital herpes was studied at different doses and regimens. OBJECTIVE:We sought to compare the clinical efficacies of the different oral antiviral drugs prescribed prophylactically to supp...

journal_title：Journal of the American Academy of Dermatology

authors： Lebrun-Vignes B,Bouzamondo A,Dupuy A,Guillaume JC,Lechat P,Chosidow O

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is caused by different species of Leishmania and transmitted by the bite of infected sand flies. It is a health problem in many countries. OBJECTIVE:This study was performed to assess the evidence for the efficacy of different therapeutic modalities for acute Old World CL, which...

journal_title：Journal of the American Academy of Dermatology

authors： Khatami A,Firooz A,Gorouhi F,Dowlati Y

更新日期：2007-08-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the occurrence of arterial and/or venous thromboembolic events and obstetric complications in the setting of circulating antiphospholipid antibodies. Dermatologic manifestations are commonly seen in APS with almost half of the patients exhi...

journal_title：Journal of the American Academy of Dermatology

authors： Kriseman YL,Nash JW,Hsu S

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Onychomycosis (OM) affects up to 10% of the general population and is associated with functional impairment. Clinically, OM can mimic nail psoriasis, trauma, lichen planus, oncyhogryphosis, and other disorders. Laboratory methods for diagnosing OM vary in accuracy and predictive value. Clinical clues to OM w...

journal_title：Journal of the American Academy of Dermatology

authors： Walling HW,Sniezek PJ

更新日期：2007-06-01 00:00:00

abstract：:We describe a 4-year-old, otherwise healthy boy with a congenital history of a perioral and labial segmental café-au-lait macule, who was noted to have unilateral localized gingival hyperpigmentation that aligned with the café-au-lait macule. This case is highly illustrative of the embryologic timing of the genetic ev...

journal_title：Journal of the American Academy of Dermatology

authors： Sergay A,Silverberg NB

更新日期：2007-05-01 00:00:00

abstract：:We describe a 6-year-old boy with a granulomatous lesion on the upper aspect of his left arm. Fusarium solani infection was confirmed by biopsy studies and cultures. The biopsy specimen showed an unusually extensive dermal invasion with fungal hyphae. This is an uncommon clinical presentation for deep cutaneous infect...

journal_title：Journal of the American Academy of Dermatology

authors： Nakamura Y,Xu X,Saito Y,Tateishi T,Takahashi T,Kawachi Y,Otsuka F

更新日期：2007-05-01 00:00:00

abstract：:Longitudinal pigmentation of the nail is very common. The differential diagnosis varies from subungual hematoma, to a fungal infection, to a melanocytic lesion (lentigo, nevus melanoma, etc.) to others. Often, dermatologists do not feel at ease with these pathologies and management is often not clear. In many cases, a...

journal_title：Journal of the American Academy of Dermatology

authors： Braun RP,Baran R,Le Gal FA,Dalle S,Ronger S,Pandolfi R,Gaide O,French LE,Laugier P,Saurat JH,Marghoob AA,Thomas L

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Junctional nevi are traditionally associated with children and younger patients. We noticed that these lesions are also often found in elderly patients. OBJECTIVE:We sought to determine if junctional nevi are found in all age groups. METHODS:All biopsy reports for junctional nevi for the year 2001 at the P...

journal_title：Journal of the American Academy of Dermatology

authors： Westhafer J,Gildea J,Klepeiss S,Clarke L,Helm K

更新日期：2007-05-01 00:00:00

abstract：DISCLAIMER:Adherence to these guidelines will not ensure successful treatment in every situation. Furthermore, these guidelines should not be deemed inclusive of all proper methods of care or exclusive of other methods of care reasonably directed to obtaining the same results. The ultimate judgment regarding the propri...

journal_title：Journal of the American Academy of Dermatology

authors： Strauss JS,Krowchuk DP,Leyden JJ,Lucky AW,Shalita AR,Siegfried EC,Thiboutot DM,Van Voorhees AS,Beutner KA,Sieck CK,Bhushan R,American Academy of Dermatology\/American Academy of Dermatology Association.

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Although etanercept is used as a continuous therapy for moderate to severe plaque psoriasis, intermittent use may be necessary in some instances. OBJECTIVE:In this randomized, open-label study, we evaluated the effectiveness and safety of continuous versus interrupted etanercept therapy. METHODS:All patien...

journal_title：Journal of the American Academy of Dermatology

authors： Moore A,Gordon KB,Kang S,Gottlieb A,Freundlich B,Xia HA,Stevens SR

更新日期：2007-04-01 00:00:00

abstract：UNLABELLED:Cutaneous vascular malformations are rare disorders representing errors in vascular development. These lesions occur much less commonly but are often confused with the common infantile hemangioma. It is important to properly diagnose vascular malformations because of their distinct differences in morbidity, ...

journal_title：Journal of the American Academy of Dermatology

authors： Garzon MC,Huang JT,Enjolras O,Frieden IJ

更新日期：2007-04-01 00:00:00

abstract：:Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service t...

journal_title：Journal of the American Academy of Dermatology

authors： Heymann WR

更新日期：2007-04-01 00:00:00

abstract：:The quest for effective strategies to treat obesity has propelled fat research into an exploration of the molecular processes that drive adipocyte formation, and hence body fat mass. The development of obesity is dependent on the coordinated interplay of adipocyte hypertrophy (increased fat cell size), adipocyte hyper...

journal_title：Journal of the American Academy of Dermatology

authors： Avram MM,Avram AS,James WD

更新日期：2007-03-01 00:00:00

abstract：:The growing investigation and use of epidermal growth factor receptor (EGFR) inhibitors in anticancer therapy has been motivated by their specificity for EGFR, which improves their ability to target cancer cells and enhances their safety profile compared with many other conventional chemotherapeutic agents. However, t...

journal_title：Journal of the American Academy of Dermatology

authors： Hu JC,Sadeghi P,Pinter-Brown LC,Yashar S,Chiu MW

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:In recent years there has been an increasing focus on human subject protection and on documentation of ethical review in published clinical research. The JAAD clearly states in its instructions to authors, which adhere to the guidelines set forth by the International Committee of Medical Journal Editors, "st...

journal_title：Journal of the American Academy of Dermatology

authors： Perkins AC,Choi JM,Kimball AB

更新日期：2007-02-01 00:00:00